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NTproBNP水平与心功能分级及LV

时间:2017-9-4 17:42:39 来源:心功能不全

研究血浆N末端B型利钠肽前体(NT-proBNP)水平与心功能分级及左室射血分数（LVEF）的相关性，探讨NT-proBNP与主要不良心血管事件（MACE）发生率的关系。

TostudythecorrelationamongNYHAcardiacfunctionclass,leftventricularejectionfraction(LVEF)andN-terminalpro-brainnatriureticpeptide(NT-proBNP)andrelationshipbetweenNT-proBNPandincidencerateofmajoradversecardiovascularevents(MACE).

选择不同心功能水平患者例(心功能正常者40例，心功能NYHA分级I级46例，Ⅱ级57例，Ⅲ级58例，Ⅳ级42例)，测定患者血NT-proBNP水平及LVEF,并分析NT-proBNP与心功能分级及LVEF的相关性；随访24个月观察NT-proBNP水平与MACE事件发生率的关系。

Atotalofpatientswithdifferentdegreecardiacfunctionwereselected,including40caseswithnormalcardiacfunction,46caseswithNYHAcardiacfunctionclassI,57caseswithNYHAcardiacfunctionclassⅡ,58caseswithNYHAcardiacfunctionclassⅢand42caseswithNYHAcardiacfunctionclassⅣ.PlasmaNT-proBNPlevelandLVEFweremeasuredandcorrelationsamongNYHAcardiacfunctionclass,LVEFandNT-proBNPwereanalyzed;allsubjectswerefollowedupfor24monthstoobservetherelationshipbetweenplasmaNT-proBNPlevelandincidencerateofMACE.

血浆NT-proBNP水平、MACE发生率随心功能分级增加而明显升高（P均=0.）；Spearman相关分析显示：NT-proBNP水平与心功能分级呈明显正相关(r=0.，P0.01)，与LVEF呈明显负相关(r=-0.，P0.01)；随着NT-proBNP水平(0～4级)升高，患者MACE发生率明显升高（分别为20%、41.3%、，50.9%、63.8%、71.4%，P=0.）。

PlasmaNT-proBNPlevelandincidencerateofMACEsignificantlyrosealongwithNYHAcardiacfunctionclassincreased,P=0.both;SpearmancorrelationanalysisindicatedthatNT-proBNPlevelwaspositivelycorrelatedwithNYHAcardiacfunctionclass(r=0.,P0.01)andinverselycorrelatedwithLVEF(r=-0.,P0.01);alongwithNT-proBNPlevelrose(0～4thclass),incidencerateofMACEsignificantlyincreased(namely20%,41.3%,50.9%,63.8%and71.4%respectively,P=0.).

N末端B型利钠肽前体与心功能分级及左室射血分数值之间具有较好的相关性，与MACE也有关系,对诊断及预后有重要价值。

NT-proBNPlevelissignificantlycorrelatedwithNYHAcardiacfunctionclassandLVEF,andrelatedwithMACEincidencerate,whichpossessesimportantdiagnosticandprognosticvalue.

作者：林茂海，黄开建，林守学

单位：医院心血管内科

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